CSL Behring Respreeza

Respreeza is used in adults with known severe alpha1-proteinase inhibitor deficiency.

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ro Romania Distributed by Prisum Healthcare.

Phone +40 021 322 0171
E-mail office@prisum.ro

What is Respreeza 

This medicine contains the active substance human alpha1-proteinase inhibitor, which is a normal component of the blood and is found in the lung.

There, its main function is to protect the lung tissue by limiting the action of a certain enzyme, called neutrophil elastase. Neutrophil elastase can cause damage if its action is not controlled (for example, in case you have an alpha1-proteinase inhibitor deficiency).

How Respreeza works

Human alpha1-proteinase inhibitor is a normal constituent of human blood. 

Human alpha1-proteinase inhibitor is understood to be the primary anti-protease in the lower respiratory tract, where it inhibits neutrophil elastase (NE).

Normal healthy individuals produce sufficient alpha1-proteinase inhibitor to control the NE produced by activated neutrophils and are thus able to prevent inappropriate proteolysis of lung tissue by NE. However, individuals deficient in endogenous alpha1-proteinase inhibitor are unable to maintain appropriate antiprotease defence and experience more rapid proteolysis of the alveolar walls starting prior to the development of clinically evident chronic obstructive lung disease in the third or fourth decade.

What Respreeza is used for

This medicine is used in adults with known severe alpha1-proteinase inhibitor deficiency (an inherited condition also called alpha1 antitrypsin deficiency) who have developed a lung condition called emphysema.
Emphysema develops when the lack of alpha1-proteinase inhibitor results in a condition in which neutrophil elastase is not being properly controlled, damaging the tiny air sacs in the lungs through which oxygen passes into the body. Because of this damage, the lungs do not work properly.
Using this medicine regularly increases the blood and lung levels of alpha1-proteinase inhibitor, thus slowing the progression of emphysema.

What does Respreeza contain

The active substance is human alpha1-proteinase inhibitor. One vial contains approximately 1,000 mg, 4,000 mg or 5,000 mg of human alpha1-proteinase inhibitor.

The other ingredients are sodium chloride, sodium dihydrogen phosphate monohydrate and mannitol (see section 2).

Solvent: Water for injections.


One pack contains:
- 1 single-use powder vial
- 1 solvent vial of 20 ml water for injections
- 1 transfer set 20/20 (Mix2Vial set) for reconstitution


The information presented above does not provide medical advice. It is intended for informational purposes only. It is not a substitute for professional medical advice, diagnosis or treatment. Seek professional medical advice to treat your condition.


Η εταιρεία CSL Behring εκπροσωπείται από την Prisum MONO στην Ρουμανία.